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  • Title: Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.
    Author: Kumagami H, Terakado M, Sainoo Y, Baba A, Fujiyama D, Fukuda T, Takasaki K, Takahashi H.
    Journal: Audiol Neurootol; 2009; 14(3):190-7. PubMed ID: 19066426.
    Abstract:
    The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs of patients with vestibular schwannoma and with Ménière's disease. TRPV4 is assumed to play a role as an osmoreceptor in cell and fluid volume regulation in the human endolymphatic sac.
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