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  • Title: Bcl-2 proteins and apoptosis: choose your partner.
    Author: Shore GC, Nguyen M.
    Journal: Cell; 2008 Dec 12; 135(6):1004-6. PubMed ID: 19070569.
    Abstract:
    The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.
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