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  • Title: Biosynthetic origins of the ionophore antibiotic indanomycin.
    Author: Roege KE, Kelly WL.
    Journal: Org Lett; 2009 Jan 15; 11(2):297-300. PubMed ID: 19072095.
    Abstract:
    The pyrroloketoindane antibiotic indanomycin is produced by Streptomyces antibioticus NRRL 8167. These hybrid nonribosomal peptide-polyketide ionophore antibiotics are characterized by the presence of an unusual indane ring system, and there is interest in identifying the biochemical mechanisms guiding its biosynthesis. Following incorporation of [1-(13)C]-labeled precursors, the primary metabolic origins of indanomycin were determined to be one unit of L-proline, six units of malonyl-CoA and two units each of methylmalonyl-CoA and ethylmalonyl-CoA.
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