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  • Title: Separation and identification of N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, a novel nucleic acid adduct of carcinogen 4-nitroquinoline 1-oxide.
    Author: Kohda K, Kawazoe Y, Minoura Y, Tada M.
    Journal: Carcinogenesis; 1991 Aug; 12(8):1523-5. PubMed ID: 1907226.
    Abstract:
    A novel nucleic acid adduct of the carcinogen 4-nitroquinoline 1-oxide, N4-(guanosin-7-yl)-4-aminoquinoline 1-oxide, was separated and identified after RNA was treated with activated 4-hydroxyaminoquinoline 1-oxide. This is the first report of a 7-arylaminated guanine adduct produced by arylaminating carcinogens.
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