These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Vascular fractal dimension and total vascular area in the study of oral cancer.
    Author: Goutzanis LP, Papadogeorgakis N, Pavlopoulos PM, Petsinis V, Plochoras I, Eleftheriadis E, Pantelidaki A, Patsouris E, Alexandridis C.
    Journal: Head Neck; 2009 Mar; 31(3):298-307. PubMed ID: 19073004.
    Abstract:
    BACKGROUND: Microvessel quantification has been studied extensively as a factor reflecting angiogenesis in various malignant tumors. The aim of our study was to evaluate the vascular fractal dimension and the immunohistochemically positive total vascular area in oral cavity carcinomas in order to assess their potential value as factors reflecting angiogenesis. METHODS: Histologic sections from 48 carcinomas and 17 nonmalignant mucosa specimens were evaluated by image analysis using fractal analysis software. Total vascular area was also quantified. RESULTS: Carcinomas presented higher mean values of vascular fractal dimension and total vascular area compared to normal mucosa. The difference for the vascular fractal dimension was statistically significant. CONCLUSIONS: This study provides evidence that vascular fractal dimension could be used as a reliable factor reflecting angiogenesis in oral squamous cell carcinoma and that there are several statistically significant correlations among total vascular area, vascular fractal dimension, nuclear size, and clinicopathologic factors.
    [Abstract] [Full Text] [Related] [New Search]