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  • Title: Malignant craniopharyngioma; case report and review of the literature.
    Author: Boongird A, Laothamatas J, Larbcharoensub N, Phudhichareonrat S.
    Journal: Neuropathology; 2009 Oct; 29(5):591-6. PubMed ID: 19077042.
    Abstract:
    A case of malignant craniopharyngioma in a 46-year-old woman presenting clinically with visual disturbance and bifrontal headache is reported. Histopathologic examination of the suprasellar mass showed a lesion characterized by nests of epithelial cells with a basaloid appearance, round-to-oval nuclei, moderate pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio and high mitotic activity. Immunohistochemically, the tumor cells were positive for Ki-67 (44.3%), p53 (98%), and p63 (100%), but negative for estrogen and progesterone receptors. Clinical and pathologic features with a brief review of the relevant literature for malignant craniopharyngioma as a novel member of tumors of the suprasellar region, is discussed.
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