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  • Title: Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease.
    Author: Filali M, Lalonde R, Rivest S.
    Journal: Genes Brain Behav; 2009 Mar; 8(2):143-8. PubMed ID: 19077180.
    Abstract:
    Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an Alzheimer's disease model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models.
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