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  • Title: Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.
    Author: Leopoldo M, Lacivita E, De Giorgio P, Contino M, Berardi F, Perrone R.
    Journal: Bioorg Med Chem; 2009 Jan 15; 17(2):758-66. PubMed ID: 19081257.
    Abstract:
    In the search for compounds with potential for development as positron emission tomography radioligands for brain D(3) receptor imaging, a series of N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides with appropriate lipophilicity (2<logP<3.5) were synthesized and tested in vitro. Some of the final compounds showed moderate-to-high dopamine D(3) receptor affinities but lacked selectivity over D(2) receptors.
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