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  • Title: Antitumour polyether macrolides: four new halichondrins from the New Zealand deep-water marine sponge Lissodendoryx sp.
    Author: Hickford SJ, Blunt JW, Munro MH.
    Journal: Bioorg Med Chem; 2009 Mar 15; 17(6):2199-203. PubMed ID: 19081259.
    Abstract:
    The isolation is reported of four new variants of the halichondrin B skeleton, very minor potently bioactive components from the Poecilosclerid sponge Lissodendoryx sp. These compounds were isolated in microgram quantities only from a collection of 1tonne of sponge. The structural elucidations relied heavily on the use of capillary NMR spectroscopy and the application of an HSQC-DEPT overlay technique.
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