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  • Title: Use of diffusion tensor imaging to examine subacute white matter injury progression in moderate to severe traumatic brain injury.
    Author: Greenberg G, Mikulis DJ, Ng K, DeSouza D, Green RE.
    Journal: Arch Phys Med Rehabil; 2008 Dec; 89(12 Suppl):S45-50. PubMed ID: 19081441.
    Abstract:
    OBJECTIVE: To demonstrate subacute progression of white matter (WM) injury (4.5mo-2.5y postinjury) in patients with traumatic brain injury using diffusion-tensor imaging. DESIGN: Prospective, repeated-measures, within-subjects design. SETTING: Inpatient neurorehabilitation program and teaching hospital MRI department. PARTICIPANTS: Brain-injured adults (N=13) with a mean Glasgow Coma Scale score of 7.67+/-4.16. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Fractional anisotropy (FA) values were measured at 4.5 and 29 months postinjury in right and left frontal and temporal deep WM tracts and the anterior and posterior corpus callosum. RESULTS: FA significantly decreased in frontal and temporal tracts: right frontal (.38+/-.06 to .30+/-.06; P<.005), left frontal (.37+/-.06 to .32+/-.06; P<.05), right temporal (.28+/-.05 to .22+/-.018; P<.005), and left temporal (.28+/-.05 to .24+/-.02; P<.05). No significant changes were in the corpus callosum. CONCLUSIONS: Preliminary results demonstrate progression of WM damage as evidenced by interval changes in diffusion anisotropy. Future research should examine the relationship between decreased FA and long-term clinical outcome.
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