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  • Title: The safety and immunogenicity of influenza vaccine in children with asthma in Mexico.
    Author: Pedroza A, Huerta JG, Garcia Mde L, Rojas A, López-Martínez I, Penagos M, Franco-Paredes C, Deroche C, Mascareñas C.
    Journal: Int J Infect Dis; 2009 Jul; 13(4):469-75. PubMed ID: 19084453.
    Abstract:
    BACKGROUND: The morbidity and mortality associated with influenza is substantial in children with asthma. There are no available data on the safety and immunogenicity of influenza vaccine in children with asthma in Latin America. Furthermore, it is unclear if influenza vaccination may cause asthma exacerbations. METHODS: We conducted a placebo-controlled trial to investigate the safety and immunogenicity of an inactivated trivalent split virus influenza vaccine in children with asthma in Mexico. We also measured the impact of influenza vaccination on pulmonary function tests in this population. RESULTS: The inactivated influenza vaccine was immunogenic and safe in terms of local and systemic side effects compared to placebo. We observed no significant impact on pulmonary function tests among vaccine recipients. CONCLUSIONS: Given the significant morbidity associated with influenza in children, strategies to promote increased influenza vaccination coverage in this high-risk group in Latin America and elsewhere are urgently needed.
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