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PUBMED FOR HANDHELDS

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  • Title: [Treatment of fistulating pouchitis with tumour necrosis factor-alpha-inhibitor (infliximab)].
    Author: Semb S, Nordgaard-Lassen I.
    Journal: Ugeskr Laeger; 2008 Dec 08; 170(50):4134-5. PubMed ID: 19091194.
    Abstract:
    The surgical first choice treatment for patients with ulcerative colitis (UC) involves total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Postoperative development of pouch-related fistula is a rare complication, but it is associated with significant morbidity, a high recurrence rate and is a major cause of pouch failure. We report the use of infliximab, a monoclonal antibody to tumour necrosis factor-alpha, in three patients who developed pouch-related fistula after undergoing IPAA surgery for UC.
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