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  • Title: [Cervical pathology: significance and therapeutic impact of margin status].
    Author: Michy T, Leveque J, Loussouarn D, Dravet F, Dejode M, Sagan C, Descamps P, Classe JM.
    Journal: Bull Cancer; 2008 Dec; 95(12):1171-5. PubMed ID: 19091650.
    Abstract:
    Margin status in cervical pathology is one of most important predictive factor of recurrent disease. Even if management of surgical biopsy is standardized, quality of surgical procedure is fundamental. Frozen section can be realise in order to complete surgical procedure if margins are involved. Extemporaneous exam of endocervical margin during conservative surgery and vaginal cuff during radical surgery is a precious information for surgeon. Endocervical status for conization, parametrial and vaginal margins have been reported to be a factor predictive of residual disease. During radical trachelectomy, margins involvment of one of these three topographic zone is an important predictive factor of recurrent disease and can be an obstacle to preserve fertility.
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