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  • Title: [The effect of nimodipine and verapamil on the blood supply and vascular reactivity of the brain].
    Author: Beketov AI, Polevik IV.
    Journal: Farmakol Toksikol; 1991; 54(2):19-21. PubMed ID: 1909246.
    Abstract:
    In experiments on conscious rabbits with electrodes implanted into the brain it was found by using hydrogen clearance method that nimodipine (0.1-0.06 mg/kg) and verapamil (0.3-1 mg/kg) increase the local blood flow to the decreasing degree in the cerebral hemispheric cortex, hypothalamus and thalamus. This is associated with a decrease in reactivity of the vessels of the above mentioned brain structures determined by the dilatory reaction to the dosed inhalation of carbon dioxide.
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