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  • Title: [Antiallergic effect of D-glucuronic acid].
    Author: Danilets MG, Bel'skiĭ IuP, Bel'skaia NF, Trofimova ES, Uchasova EG, Ligacheva AA, Agafonov VI.
    Journal: Eksp Klin Farmakol; 2008; 71(5):37-9. PubMed ID: 19093370.
    Abstract:
    The influence of D-glucuronic acid (course administration) on a Thl and Th2 immune response was studied. It is established that D-glucuronic acid suppressed Th2-dependent immune response as it decreased the lethality from the anaphylactic shock, abolished the local anaphylactic reaction and strongly inhibited allergen-specific IgE and IgG1 production. In addition, D-glucuronic acid stimulated Thl-dependent immune response since it enhanced the delay-type hypersensitivity reaction, increased amount of antibody-forming cells and the number of antibodies in blood. It is concluded that the mechanism of the antiallergic effect of D-glucuronic acid is related to a change in the Th1/Th2 balance in favor of Th1.
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