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  • Title: Stereospecific high-performance liquid chromatographic determination of tocainide.
    Author: Carr RA, Foster RT, Freitag D, Pasutto FM.
    Journal: J Chromatogr; 1991 May 03; 566(1):155-62. PubMed ID: 1909341.
    Abstract:
    A sensitive high-performance liquid chromatographic assay was developed for the determination of tocainide enantiomers in plasma. Following extraction of tocainide from plasma, the enantiomers were derivatized with S-(+)-1-(1-naphthyl)ethylisocyanate. The resulting diastereomers were separated and quantified using normal-phase chromatography with fluorescence detection set at 220/345 nm (excitation/emission). The peaks, resolved with a resolution factor greater than 1.5, were free from interference. Linearity was established over the concentration range 0.25-10.0 mg/l for each enantiomer in plasma (r2 greater than 0.998). The inter-assay variability was less than 10% at all concentrations examined. The method can be used to determine the pharmacokinetics of tocainide enantiomers in man.
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