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  • Title: Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats.
    Author: Heiene R, Rumsby G, Ziener M, Dahl SA, Tims C, Teige J, Ottesen N.
    Journal: J Feline Med Surg; 2009 Jun; 11(6):474-80. PubMed ID: 19095478.
    Abstract:
    Two unrelated Ragdoll cat mothers in Norway were found dead from renal disease. The histopathology was consistent with oxalate nephrosis with chronic or acute-on-chronic underlying kidney disease. Both cats had offspring and relatives with signs of urinary tract disease, including a kitten dead with urethral gravel. Eleven living Ragdoll cats, including nine relatives of the dead cats and the male father of a litter with similarly affected animals, were tested for primary hyperoxaluria (PH) type 1 and 2 by urine oxalate and liver enzyme analysis. Renal ultrasound revealed abnormalities in five living cats. One of these was azotaemic at the time of examination and developed terminal kidney disease 9 months later. A diagnosis of PH was excluded in 11 cats tested. The inheritance and aetiological background of the renal disease present in the breed remains unresolved at this point in time.
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