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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study.
    Author: Moisa M, Pohmann R, Ewald L, Thielscher A.
    Journal: J Magn Reson Imaging; 2009 Jan; 29(1):189-97. PubMed ID: 19097080.
    Abstract:
    PURPOSE: To develop and test a novel method for coil placement in interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) studies. MATERIALS AND METHODS: Initially, a desired TMS coil position at the subject's head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on five subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the blood oxygenation level-dependent (BOLD) responses to short repetitive TMS (rTMS) trains were assessed using echo-planar imaging (EPI) recordings. RESULTS: The spatial accuracy of our method is in the range of 2.9 +/- 1.3 (SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditory related brain areas, with the activation in M1 being localized in the hand knob. CONCLUSION: We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.
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