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  • Title: Synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy.
    Author: Minami Y, Kajimoto K, Kawana M, Hagiwara N, Sherrid MV.
    Journal: Int J Cardiol; 2010 May 28; 141(2):195-7. PubMed ID: 19097655.
    Abstract:
    This study examines acute effect of dual-chamber (DDD) pacing combined with disopyramide for left ventricular outflow tract (LVOT) gradient reduction in obstructive hypertrophic cardiomyopathy (HCM) patients. Among 24 patients refractory to maximal drug therapy, 7 had a significant improvement of LVOT gradient by DDD pacing alone. In the remaining 17 patients, the LVOT gradient reduction was 26+/-19% after DDD pacing alone and 35+/-16% after intravenous disopyramide alone. In contrast, after the combined therapy of DDD pacing and disopyramide, pressure gradient decreased from 102+/-35 to 28+/-23 mm Hg, a reduction of 72+/-21%. We have demonstrated synergy between DDD pacing and disopyramide for LVOT gradient reduction in obstructive HCM. Study of the long-term effects of this combined therapy would be the next step to ascertain clinical utility.
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