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  • Title: Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope.
    Author: Simerska P, Lu H, Toth I.
    Journal: Bioorg Med Chem Lett; 2009 Feb 01; 19(3):821-4. PubMed ID: 19097790.
    Abstract:
    Group A streptococcus is a Gram-positive bacteria that causes a range of infectious diseases. Targeting the bacteria, a new self-adjuvanting vaccine candidate, incorporating a carbohydrate carrier and an amino acid-based adjuvant, was synthesised utilising carbohydrate chemistry and solid-phase peptide synthesis procedures. Characterisation of the candidate was achieved using reverse-phase HPLC and electrospray ionisation mass spectrometry. The successful synthesis and characterisation of the vaccine candidate may contribute to the discovery of a therapeutically and clinically viable vaccine against group A streptococcus.
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