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  • Title: Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents.
    Author: Xu S, Luo Y, Graeser R, Warnecke A, Kratz F, Hauff P, Licha K, Haag R.
    Journal: Bioorg Med Chem Lett; 2009 Feb 01; 19(3):1030-4. PubMed ID: 19097889.
    Abstract:
    In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice.
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