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  • Title: [Presence of specific mutation of Ha-ras oncogene in skin tumors of mice induced under different experimental conditions].
    Author: Loktionov AS, Popovich IG, Zabezhinskiĭ MA, Anisimov VN.
    Journal: Biull Eksp Biol Med; 1991 Apr; 111(4):398-400. PubMed ID: 1909909.
    Abstract:
    The mutation was revealed with substitution of A for T in the second position of the 61 Ha-ras oncogene codon in the DNA of 31 skin tumours (26 papillomas and 5 carcinomas) and in 23 mice treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA). Part of these mice were F progeny (n-6) and F progeny (n-4) following DMBA administration during pregnancy, another part F progeny (n-5) following ENU action on males prior to mating, the rest mice (n-3) did not undergo additional actions. The mutation under study was revealed only in 3 out of 5 papillomas and in all 5 carcinomas of mice subjected to DMBA administration during pregnancy.
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