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  • Title: Palladium-catalyzed decarboxylative coupling of alkynyl carboxylic acids and aryl halides.
    Author: Moon J, Jang M, Lee S.
    Journal: J Org Chem; 2009 Feb 06; 74(3):1403-6. PubMed ID: 19099411.
    Abstract:
    2-Octynoic acid and phenylpropiolic acid were employed for the palladium-catalyzed decarboxylative coupling reaction and with a variety of aryl halides. The former needed 1,4-bis(diphenylphosphino)butane (dppb) as a ligand and the latter tri-tert-butylphosphine (P(t)Bu(3)), and both required 2 equiv of tetra-n-butylammonium fluoride (TBAF) for full conversion. These reactions showed high reactivities and tolerance of functional groups such as vinyl, ester, ether, ketone, and amine.
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