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  • Title: Low serum levels of alpha-interferon, gamma-interferon, and interleukin-2 in alcoholic cirrhosis.
    Author: Vicente-Gutiérrez MM, Diez Ruiz A, Gil Extremera B, Bermúdez García JM, Gutiérrez Gea F.
    Journal: Dig Dis Sci; 1991 Sep; 36(9):1209-12. PubMed ID: 1909948.
    Abstract:
    The existence of cellular immune deficit in alcoholic cirrhosis, together with the role of alpha- and gamma-interferon and interleukin-2 in the immune system, led us to compare serum levels of these immune system mediators in a group of 40 patients with alcoholic cirrhosis classified according to Child-Pugh's grade of severity of liver disease and 23 healthy volunteers. Serum levels of alpha-IFN, gamma-IFN, and IL-2 were significantly depressed in alcoholic cirrhotics, with no significant differences between the different degrees of hepatic damage. The results suggest a profound alteration in the immune system of alcoholic cirrhotics, which may contribute to the development of the disease and the accompanying immune system deficit.
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