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  • Title: [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction].
    Author: Sun T, Shen LH, Chen H, Li HW, Guo CY, Li ZZ, Tang CS.
    Journal: Zhonghua Xin Xue Guan Bing Za Zhi; 2008 Jan; 36(1):68-71. PubMed ID: 19099933.
    Abstract:
    OBJECTIVE: To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI). METHODS: MI was induced in male Sprague-Dawley rats by ligating the left coronary artery. Rats randomly received saline, carvedilol (10 mg.kg(-1).d(-1)) or metoprolol (20 mg.kg(-1).d(-1)) beginning at 4 weeks post MI for 8 weeks per gavage. Sham-operated rats serve as control. Collagen perivascular circumferential collagen area (PCVA), peri-coronary circumferential collagen area (VLCA) and interstitial collagen volume fraction (ICVF) as well as myocardial hydroxyproline content were determined after hemodynamic measurements at the study end. RESULTS: LVEDP were significantly lower and +/- dp/dt significantly higher in carvedilol and metoprolol treated MI rats than that in saline treated MI rats. Myocardial hydroxyproline, PCVA/VLCA ratio and ICVF were significantly reduced in metoprolol, more significantly reduced in carvedilol treated MI rats compared to saline treated MI rats (all P < 0.05). CONCLUSION: Metoprolol and carvedilol could decrease the concentration of hydroxyproline and ICVF in MI rats.
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