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  • Title: Methods of calculating protein hydrophobicity and their application in developing correlations to predict hydrophobic interaction chromatography retention.
    Author: Mahn A, Lienqueo ME, Salgado JC.
    Journal: J Chromatogr A; 2009 Mar 06; 1216(10):1838-44. PubMed ID: 19100553.
    Abstract:
    Hydrophobic interaction chromatography (HIC) is a key technique for protein separation and purification. Different methodologies to estimate the hydrophobicity of a protein are reviewed, which have been related to the chromatographic behavior of proteins in HIC. These methodologies consider either knowledge of the three-dimensional structure or the amino acid composition of proteins. Despite some restrictions; they have proven to be useful in predicting protein retention time in HIC.
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