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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Extrudable core system: development of a single-layer osmotic controlled-release tablet.
    Author: Waterman KC, MacDonald BC, Roy MC.
    Journal: J Control Release; 2009 Mar 19; 134(3):201-6. PubMed ID: 19100796.
    Abstract:
    A new controlled-release, extrudable core system (ECS) tablet has been developed which osmotically delivers high doses of low solubility active pharmaceutical ingredients (API's). The tablet has a single core formed in a modified oval shape with a semi-permeable coating. The core contains hydroxyethylcellulose, which serves to entrain the API particles as they are extruded out a hole in the coating at one end of the tablet, and a sugar, which provides the osmotic driving force for water imbibing. The dosage form has been successfully shown to control delivery of API over a range of delivery rates even with 50% of the tablet being API (up to about 500 mg).
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