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  • Title: Sirolimus treatment for recurrent lymphangioleiomyomatosis after lung transplantation.
    Author: Chen F, Omasa M, Kondo N, Fujinaga T, Shoji T, Sakai H, Bando T.
    Journal: Ann Thorac Surg; 2009 Jan; 87(1):e6-7. PubMed ID: 19101258.
    Abstract:
    Pulmonary lymphangioleiomyomatosis is a rare disease that generally progresses to respiratory failure. We experienced a patient who had recurring lymphangioleiomyomatosis in the transplanted lungs. A chest computed tomographic scan showed a progressing emphysematous change. The patient had a subclinical extent of pan-circumferential stricture at the distal site of the left bronchial anastomosis. We treated the patient with sirolimus for three years. Chest computed tomography showed no sign of exacerbation during the late 3 years, whereas pulmonary function test revealed a slight increase after the use of sirolimus. Bronchial stricture also disappeared almost completely. This is the first reported case with sirolimus treatment for post-transplant recurrent lymphangioleiomyomatosis.
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