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  • Title: Febrile ulceronecrotic Mucha-Habermann disease associated with herpes simplex virus type 2.
    Author: Smith JJ, Oliver GF.
    Journal: J Am Acad Dermatol; 2009 Jan; 60(1):149-52. PubMed ID: 19103367.
    Abstract:
    Febrile ulceronecrotic Mucha-Habermann disease is a rare severe variant of pityriasis lichenoides et varioliformis acuta, a disease within the pityriasis lichenoides spectrum of disorders. It remains uncertain whether these disorders are preneoplastic or reactive against infectious or other antigenic stimuli. Febrile ulceronecrotic Mucha-Habermann disease varies in severity and may be accompanied by a range of systemic symptoms. We present a case associated with herpes simplex virus infection. In this case, no significant T cell clone was identified. Clonality may be a prognostic marker, but reports with T-cell receptor polymerase chain reaction results are limited to eight previous cases, and further reports are required. Awareness of the condition is important because of its fulminant potential.
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