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  • Title: Autologous chondrocyte implantation of the ankle: a 2- to 5-year follow-up.
    Author: Nam EK, Ferkel RD, Applegate GR.
    Journal: Am J Sports Med; 2009 Feb; 37(2):274-84. PubMed ID: 19104032.
    Abstract:
    BACKGROUND: Treatment of full-thickness talar cartilage defects that have failed previous surgery is problematic without a definitive solution. PURPOSE: To report the first US prospective study of autologous chondrocyte implantation of the talus. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Eleven patients (6 women and 5 men; mean age, 33 years) underwent autologous chondrocyte implantation of the talus after previous failed surgical management. There were 9 medial and 2 lateral lesions, with a mean size of 21 x 13 mm (273 mm2). Five patients underwent autologous chondrocyte implantation of the talus alone; 6 had it with a "sandwich procedure." Ten patients underwent a second-look arthroscopy with screw removal. RESULTS: Mean follow-up was 38 months. Preoperatively, 10 patients rated their ankles as poor and 1 as fair, using the simplified symptomatology evaluation. At latest follow-up, 3 patients were classified as excellent, 6 as good, and 2 as fair. Tegner activity level improved from 1.3 +/- 1.0 (mean +/- SE) preoperatively to 4.0 +/- 1.6 (P < .002) postoperatively. The Finsen score (modified Weber score) showed significant improvement in the total score (P < .001). There was also overall agreement between the Finsen score and the American Orthopaedic Foot and Ankle Society ankle hindfoot score, with significant improvement from 47.4 +/- 17.4 preoperatively to 84.3 +/- 8.1 postoperatively (P < .001). At repeat arthroscopy, complete coverage of the defect was seen in all patients. CONCLUSION: Autologous chondrocyte implantation of the talus yields significant functional improvement; however, further investigation is necessary to determine the long-term structural and biomechanical properties of the repair tissue.
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