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  • Title: Tyrosinase expression and melanogenesis in melanotic and amelanotic B16 mouse melanoma cells.
    Author: Burchill SA, Bennett DC, Holmes A, Thody AJ.
    Journal: Pathobiology; 1991; 59(5):335-9. PubMed ID: 1910528.
    Abstract:
    Tyrosinase activity, abundance, and mRNA transcription were examined in three sublines of the B16 mouse melanoma. Tyrosinase activity and melanin content were highest in the B16-F1 cells, slightly less in the B16-F10, and markedly lower in the B16-F10-DD cells. No differences in the level of tyrosinase mRNA or protein were found in the three different sublines. Thus, the differences in tyrosinase expression arise from the post-translational modification of the enzyme causing its activation or inhibition.
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