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  • Title: [Study on adjuvant MTX-5-FU intraperitoneal chemotherapy for advanced gastric cancer].
    Author: Maruyama M, Nagahama T, Sato E, Maruyama S, Sanada T, Koide A, Ohhinata R, Ebana H.
    Journal: Gan To Kagaku Ryoho; 2008 Nov; 35(12):1993-5. PubMed ID: 19106501.
    Abstract:
    The intraperitoneal administration of anti-cancer drug is a rationale route to adjuvant chemotherapy. We applied adjuvant MTX-5-FU intraperitoneal chemotherapy for 60 advanced gastric cancer cases which had undergone gastrectomy (Stage II 18, Stage III A 19, Stage IIIB 13, and Stage IV 10 cases). A 5-year survival rate of Stage II, III A, IIIB and IV was 66.2%, 60.7%, 46.5% and 18.8%, respectively. Five-year survival rates of both Stage III A and IIIB on this study were likely to be higher than the rates of Stage III A and IIIB of other institutions. The 24 out of 42 cases with the serosal surface exposure of cancer demonstrated a cancer recurrence. Seventy percent (17 cases) of the 24 recurred cases developed a peritoneal recurrence, which means that the intraperitoneal chemotherapy did not touch a pattern of the recurrence of the gastric cancer with the serosal surface exposure.
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