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  • Title: [Hemorrhagic vesicle-bullous lesions in Henoch-Schönlein purpura and review of literature].
    Author: Júnior CR, Yamaguti R, Ribeiro AM, Melo BA, Campos LA, Silva CA.
    Journal: Acta Reumatol Port; 2008; 33(4):452-6. PubMed ID: 19107090.
    Abstract:
    INTRODUCTION: The characteristic feature of Henoch-Schönlein purpura (HSP) is palpable purpura, however hemorrhagic vesicles and blisters have been rarely reported. CASE REPORTS: From January 1983 to December 2007, 5079 patients were followed in our Pediatric Rheumatology Unit, 232 (4.6%) of them with the diagnosis of HSP. Three female patients (1.3%) presented hemorrhagic vesicles and bullous lesions associated with palpable purpura. In one case the lesions were severe and widespread, and in another they preceded the typical purpuric lesions. In both cases, skin biopsy disclosed leukocytoclastic vasculitis with IgA and C3 deposits. Two patients healed with residual lesions: ulcers in one case and skin hyperpigmentation in two of them. DISCUSSION: Hemorrhagic vesicle-bullous lesions are rare in HSP. This manifestation may represent a more severe and prolonged disease course with scars or may precede typical skin lesions.
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