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  • Title: Optical aggregation of metal nanoparticles in a microfluidic channel for surface-enhanced Raman scattering analysis.
    Author: Tong L, Righini M, Gonzalez MU, Quidant R, Käll M.
    Journal: Lab Chip; 2009 Jan 21; 9(2):193-5. PubMed ID: 19107272.
    Abstract:
    Aggregated metal nanoparticles exhibit enhanced localized electromagnetic fields that enable highly sensitive vibrational spectroscopy analysis based on surface-enhanced Raman scattering (SERS). We demonstrate SERS detection of organic analytes adsorbed to optically aggregated silver nanoparticles in a microfluidic device. The combination of optical tweezers and microfluidics technologies paves the way for novel lab-on-a-chip based plasmonic chemo/bio sensors and overcomes two important drawbacks of standard SERS sensing schemes; i.e. the renewal of nanofabricated metallic substrates and the difficulty of avoiding uncontrolled aggregation in metal colloids.
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