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  • Title: Relationship of polymorphisms located in tumor necrosis factor region and HLA loci among Croatians.
    Author: Stingl K, Grubic Z, Car H, Zunec R.
    Journal: Am J Hum Biol; 2009; 21(2):220-3. PubMed ID: 19107922.
    Abstract:
    Polymorphism of TNFa, TNFb, and TNFd microsatellites, linkage disequilibrium (LD) within TNF region as well as relationship of TNF microsatellites with alleles at HLA-A, -B, and -DRB1 loci was investigated on a sample of 160 Croatians, previously typed for HLA-A, -B, and -DRB1 loci. Analysis of the relationship of TNF alleles and HLA specificities revealed that very strong associations exist between TNFa2, TNFb3, and TNFd2 alleles and HLA-A*01, -B*08, and -DRB1*03 specificities, therefore placing them in the 8.1 ancestral haplotype. Similar findings were observed for TNFa11, TNFb4, and TNFd4 alleles and HLA specificities, which are a part of the 7.1 ancestral haplotype. Finally, multiple associations with significant P-values were also observed between TNFa10, TNFb4, and TNFd4 microsatellite alleles and HLA-A*02, -B*18, -DRB1*11 specificities which form the 18.3 ancestral hapolotype.
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