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  • Title: Cytochrome bd confers nitric oxide resistance to Escherichia coli.
    Author: Mason MG, Shepherd M, Nicholls P, Dobbin PS, Dodsworth KS, Poole RK, Cooper CE.
    Journal: Nat Chem Biol; 2009 Feb; 5(2):94-6. PubMed ID: 19109594.
    Abstract:
    The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.
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