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  • Title: Multivalent iminosugars to modulate affinity and selectivity for glycosidases.
    Author: Diot J, García-Moreno MI, Gouin SG, Ortiz Mellet C, Haupt K, Kovensky J.
    Journal: Org Biomol Chem; 2009 Jan 21; 7(2):357-63. PubMed ID: 19109682.
    Abstract:
    A series of mono-, di- and tri-valent iminosugars based on oligoethylene scaffolds and N-substituted deoxynojirymicin epitopes have been synthesized by "click chemistry" to study the effect of multivalency on glycosidase inhibition. Biological evaluation evidenced differences in the inhibition trends as a function of the enzyme nature. The results demonstrate that multivalency can be used in some case to modulate both the affinity and the selectivity of glycosidase inhibition.
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