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  • Title: [Diagnosis and treatment of adult growth hormone deficiency (aGHD) resulting from brain injury--role of aGHD].
    Author: Arita K, Hirano H, Tominaga A, Kurisu K.
    Journal: Brain Nerve; 2008 Dec; 60(12):1445-54. PubMed ID: 19110756.
    Abstract:
    Adult growth hormone deficiency (aGHD) has been widely accepted in endocrinological practice. The primary cause of aGHD has been considered to be hypothalamic-pituitary lesions. Traumatic brain injury and subarachnoid hemorrhage have, however, been emerging as important etiologies of aGHD in recent years. Considering the high incidences of these brain injuries and significant rate of hypopituitarism in the survivors, the impact of aGHD on public health should be much larger than it is generally considered. Patients with aGHD may present with reduced lean body mass, increased body adiposity, reduced muscle strength and exercise capacity, thin and dry skin, cool, peripheries and impaired psychological well-being. The peak GH level should be under 3ng/mL when tested by the insulin tolerance, arginine, L-DOPA, or glucagon tests in aGHD patients. The peak GH value should be under 9 ng/mL when tested by the GHRP-2 test, this test is currently available only in Japan, and is a safe and quick method to assess the GH secretory function. A low level of IGF-1 may be an indicator of GHD in the presence of hypopituitarism, but a normal IGF-I does not rule out GHD. The GH replacement dose should be adjusted according to the normal physiology in order to minimize the risk of side effects. GH replacement may influence the metabolism of thyroid, glucocorticoid hormone, and increase the requirement of hormones. Long-term GH replacement therapy has been reported to improve the morbidity and moratlity of aGHD. Although there is no evidence to prove that GH replacement increases the risk of recurrence of tumor, de-novo neoplasm, or serious cardiovascular disease, the long-term safety of GH replacement should be rigorously monitored.
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