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  • Title: Microheterogeneity of urinary albumin and tubular proteinuria in juvenile diabetes mellitus.
    Author: Ries M, Schärer K, Wartha R, Schmidt H, Gekle D.
    Journal: Pediatr Nephrol; 1991 Sep; 5(5):582-6. PubMed ID: 1911142.
    Abstract:
    We studied differential urinary albumin excretion by a double one-dimensional gel electrophoresis with decyl sodium sulphate-polyacrylamide gel electrophoresis in the first, and isoelectric focusing in the second dimension in 37 diabetic children and 20 healthy subjects. In addition, total proteins, albumin, beta 2-microglobulin and molecular size distribution of urinary proteins were measured, the latter using sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Whilst albuminuria was not significantly different from controls we found an increased microheterogeneity of urinary albumin in 38% of patients. In addition, low molecular weight protein (P less than 0.05) and beta 2-microglobulin excretion (P less than 0.01) were elevated. It is suggested that the appearance of highly heterogenous albumin in the pI range of 5.3-5.9 is the result of a decreased tubular reabsorption.
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