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  • Title: Synthesis and biological activity of novel shikonin analogues.
    Author: Wang W, Dai M, Zhu C, Zhang J, Lin L, Ding J, Duan W.
    Journal: Bioorg Med Chem Lett; 2009 Feb 01; 19(3):735-7. PubMed ID: 19111464.
    Abstract:
    A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1alpha in breast cancer cells MDA-MB-231 under hypoxia. The features of these analogues suggest their potential in cancer therapy.
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