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  • Title: Curing APL: differentiation or destruction?
    Author: Kogan SC.
    Journal: Cancer Cell; 2009 Jan 06; 15(1):7-8. PubMed ID: 19111876.
    Abstract:
    In a recent issue of Nature Medicine, Nasr et al. show that the effectiveness of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia is independent of their ability to cause differentiation. Targeted destruction of the PML-RARalpha oncoprotein appears key to eliminating the cells from which relapse can arise.
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