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  • Title: Daptomycin for methicillin-resistant Staphylococcus aureus infections of the spine.
    Author: Burdette SD.
    Journal: Spine J; 2009 Jun; 9(6):e5-8. PubMed ID: 19112049.
    Abstract:
    BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) infection is increasingly common. Treatment with vancomycin-based therapy is often unsuccessful. Daptomycin is a relatively new lipopeptide antibiotic with potent activity against MRSA. PURPOSE: To describe the successful management of MRSA infection involving the spine. STUDY DESIGN: Two case reports of MRSA infection, one involving epidural and lumbar subdural abscesses, the other with osteomyelitis and discitis. METHODS: Two cases are described, one with lumbar epidural and subdural abscesses and the other with osteomyelitis and discitis of the spine. Switching from vancomycin to daptomycin plus rifampin-based therapy resulted in patient improvement that allowed discharge from the hospital. RESULTS: Both patients recovered fully from their infection. CONCLUSIONS: Daptomycin is a safe and effective option for the treatment of MRSA infection involving the spine.
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