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  • Title: Coffee consumption and risk of breast cancer: a metaanalysis.
    Author: Tang N, Zhou B, Wang B, Yu R.
    Journal: Am J Obstet Gynecol; 2009 Mar; 200(3):290.e1-9. PubMed ID: 19114275.
    Abstract:
    OBJECTIVE: This metaanalysis was conducted to assess the association between coffee consumption and breast cancer risk. STUDY DESIGN: Relevant studies were identified by searching Medline (1966-May 2008) and the reference lists of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated using a random-effects model. RESULTS: Nine cohort and 9 case-control studies met the inclusion criteria. The combined RR showed a borderline significant influence of highest coffee consumption (RR, 0.95; 95% CI, 0.90-1.00) or an increment of 2 cups/day of coffee consumption (RR, 0.98; 95% CI, 0.96-1.00) on the risk of breast cancer. In stratified analysis, borderline significant associations were observed among cohort and case-control studies and studies conducted in Europe and the United States. However, no significant association was noted among studies conducted in Asia. CONCLUSION: Our findings suggest a possible influence of high coffee consumption or an increased coffee consumption on the risk of breast cancer.
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