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  • Title: Neural precursor cell lines promote neurite branching.
    Author: Neville CM, Huang AY, Shyu JY, Snyder EY, Hadlock TA, Sundback CA.
    Journal: Int J Neurosci; 2009; 119(1):15-39. PubMed ID: 19116829.
    Abstract:
    Schwann cells and primary progenitor cells improve regeneration across peripheral nerve defects. This study examined the impact of immortalized neural precursor cells on regeneration of rat nerve defects. Across 10-mm gaps, neuromas formed without neural cables with C17.2- or RN33B-transplanted cells, but neural cables formed across 5-mm gaps seeded with RN33B cells. In vitro, dorsal root ganglia neurites elongated across Schwann and RN33B cells; RN33B cells induced neurite branching with shorter total outgrowth. Neural cable formation in vivo was likely determined by the balance of guidance and branch-inducing factors secreted by Schwann and transplanted precursor cells.
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