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  • Title: A simple method to monitor serum concentrations of fluoxetine and its major metabolite for pharmacokinetic studies.
    Author: Franceschi L, Faggiani A, Furlanut M.
    Journal: J Pharm Biomed Anal; 2009 Feb 20; 49(2):554-7. PubMed ID: 19117710.
    Abstract:
    A rapid, selective and sensitive isocratic reversed-phase HPLC assay coupled with MS/MS detection for simultaneous quantification of fluoxetine and its major active metabolite in serum samples has been developed. Analytes were extracted with a simple three step liquid-liquid procedure and chromatographic separation was achieved on a C18 column. Because of its sensitivity, this HPLC/MS/MS method is suitable both for routine therapeutic drug monitoring and for pharmacokinetic studies, due to its low limits of quantification.
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