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  • Title: A proportion of rat liver mitochondrial carnitine palmitoyltransferase can be made activatable by malonyl-CoA.
    Author: Ghadiminejad I, Saggerson D.
    Journal: Biochim Biophys Acta; 1991 Oct 01; 1085(3):377-80. PubMed ID: 1911872.
    Abstract:
    Treatment of rat liver mitochondrial membranes with cholate yields a soluble extract containing carnitine palmitoyltransferase (CPT) activity that is insensitive to malonyl-CoA. As found previously (I. Ghadiminejad and D. Saggerson (1990) FEBS Lett. 269, 406-408), addition of polyethylenen glycol 6000 (PEG 6000) to this extract conferred sensitivity to malonyl-CoA on the CPT. It is now shown that a sub-population of the CPT activity which is sedimentable at 7000 x g after addition of PEG 6000 is activated by malonyl-CoA, whereas the remainder is inhibited by malonyl-CoA. The presence of KCl increases the proportion of the activatable form of CPT. Possible physiological significance of this finding is discussed.
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