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  • Title: Differences in lipogenesis in tissues of control and gold-thioglucose obese mice after an isocaloric meal.
    Author: Blair SC, Cooney GJ, Denyer GS, Williams PF, Caterson ID.
    Journal: Biochim Biophys Acta; 1991 Oct 01; 1085(3):385-8. PubMed ID: 1911874.
    Abstract:
    Lipogenesis was measured in 2 and 5 week gold-thioglucose (GTG) obese mice after a single meal of 0.5 g of standard chow. Compared to control mice the rate of lipogenesis in GTG obese mice, was 4-fold higher in liver and 10-fold higher in white adipose tissue (WAT). In brown adipose tissue (BAT) of GTG-injected mice the lipogenic rate was only 50% of that of controls. These results indicate that the increased lipid synthesis observed in GTG-injected mice is not due solely to hyperphagia and that some other stimuli, such as increased basal insulin levels and/or decreased thermogenesis and insulin resistance in BAT, contribute to the high rates of fat synthesis in this animal model of obesity.
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