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  • Title: [Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy].
    Author: Toumi S, Hammouda M, Essid A, Medimagh L, Slamia LB, Laouani-Kechrid C.
    Journal: Med Mal Infect; 2009 Dec; 39(12):906-8. PubMed ID: 19118962.
    Abstract:
    INTRODUCTION: Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections. Its neurologic toxicity is rare but can be serious. CASE REPORT: We report the case of a 27-year-old male patient, treated with metronidazole for a cerebral abscess. He presented with a cerebellar syndrome and peripheral neuropathy at a cumulative metronidazole dose of 60g. The MRI aspect of the cerebellar lesions in addition to their reversibility after treatment cessation led to the diagnosis of metronidazole induced neurologic toxicity. CONCLUSION: The occurrence of neurologic disorders in patients treated with metronidazole must suggest drug toxicity and lead to cessation of treatment.
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