These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study.
    Author: MacFarlane JG, Cleghorn JM, Brown GM, Streiner DL.
    Journal: Biol Psychiatry; 1991 Aug 15; 30(4):371-6. PubMed ID: 1912128.
    Abstract:
    The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study. Melatonin (75 mg per os) or identical placebo was administered at 10 PM daily to 13 insomniac patients for 14 consecutive days. A significant increase in the subjective assessment of total sleep time and daytime alertness was demonstrated with melatonin but not with placebo. However, 7 of the 13 patients reported that the active treatment had no significant effect on subjective feelings of well-being.
    [Abstract] [Full Text] [Related] [New Search]