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  • Title: Congenital stage 1 neuroblastoma evolved into stage 4s.
    Author: Schiavetti A, Foco M, Ingrosso A, Chiriacò D, Ballesio L.
    Journal: J Pediatr Hematol Oncol; 2009 Jan; 31(1):59-60. PubMed ID: 19125091.
    Abstract:
    A newborn with a prenatally detected adrenal mass underwent complete resection of a stage 1 favorable histology neuroblastoma (NB) without MYC-N amplification. Two months later, the infant presented with a local recurrence and multiple hepatic metastases. Close follow-up without therapy was adopted for stage 4s NB. Enlarging tumor lesions were seen until the child was 8 months old, followed by later decrease in size. At 36 months of follow-up, the child is alive and disease-free. We describe this case of NB and its abnormally short evolution from stage 1 to stage 4s, despite initial surgery. Its spontaneous regression may help us understand the natural history of congenital NB.
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